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Relationship between levels of inflammatory cytokines in the genital tract and CD4+ cell counts in women with acute HIV-1 infection.

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dc.contributor.authorBebell, Lisa M.
dc.contributor.authorPassmore, Jo-Ann Shelley.
dc.contributor.authorWilliamson, Carolyn.
dc.contributor.authorMlisana, Koleka Patience.
dc.contributor.authorIriogbe, Itua.
dc.contributor.authorvan Loggerenberg, Francois.
dc.contributor.authorAbdool Karim, Quarraisha.
dc.contributor.authorAbdool Karim, Salim Safurdeen.
dc.date.accessioned2013-04-26T13:05:23Z
dc.date.available2013-04-26T13:05:23Z
dc.date.created2008
dc.date.issued2008
dc.descriptionPresented in part: VIIIth Microbicides Conference, Cape Town, South Africa, April 2006 (abstract 343); XVIth AIDS Conference, Toronto, Canada, August 2006 (abstract MOAX0102); AIDS Immunology Conference, Kampala, Uganda, December 2006.en
dc.description.abstractInflammatory responses at mucosal surfaces after human immunodeficiency virus type 1 (HIV-1) transmission may influence disease outcome.We evaluated levels of interleukin (IL)–1B , IL-6, tumor necrosis factor– a, IL-8, IL-10, and IL-12 in genital tract and plasma specimens from 44 women with acute HIV infection and 29 HIV-negative control women (13 of whom were women in the acute HIV infection cohort who had preinfection samples available for analysis). Women with acute HIV infection had significantly elevated levels of IL-6, IL-10, and IL-12 in genital tract specimens and elevated levels of IL-1B , IL-8, and IL-10 in plasma specimens, compared with HIV-negative control women. Levels of IL-1B , IL-6, and IL-8 in cervicovaginal specimens from women with acute HIV infection showed a significant inverse correlation with systemic CD4 + cell counts, suggesting that mucosal inflammation is associated with low CD4 + cell counts during acute HIV infection.en
dc.identifier.citationBebell, L.M., et al. 2008. Relationship between levels of inflammatory cytokines in the genital tract and CD4+ cell counts in women with acute HIV-1 infection. Journal of Infectious Diseases 198(5) pp. 710-714.en
dc.identifier.issn1537-6613
dc.identifier.urihttp://dx.doi.org/10.1086/590503en
dc.identifier.urihttp://hdl.handle.net/10413/8803
dc.language.isoenen
dc.publisherThe Infectious Diseases Society of America.en
dc.subjectHIV infections--Transmission.en
dc.subjectHIV infections--Treatment.en
dc.subjectAIDS (Disease) in women.en
dc.subject.otherMucosal inflammation.en
dc.subject.otherAcute HIV-1 infection.en
dc.subject.otherLow CD4+ counts.en
dc.titleRelationship between levels of inflammatory cytokines in the genital tract and CD4+ cell counts in women with acute HIV-1 infection.en
dc.typePeer reviewed journal articleen

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