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HIV incidence in young girls in KwaZulu-Natal, South Africa - public health imperative for their inclusion in HIV biomedical intervention trials.

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dc.contributor.authorAbdool Karim, Quarraisha.
dc.contributor.authorKharsany, Ayesha Bibi Mahomed.
dc.contributor.authorWerner, Lise.
dc.contributor.authorMlotshwa, Mukelisiwe.
dc.contributor.authorMadlala, Bernadette T.
dc.contributor.authorAbdool Karim, Salim Safurdeen.
dc.contributor.authorFröhlich, Janet Ann.
dc.date.accessioned2012-11-23T06:47:26Z
dc.date.available2012-11-23T06:47:26Z
dc.date.created2012
dc.date.issued2012
dc.description.abstractYoung women are particularly vulnerable for acquiring HIV yet they are often excluded from clinical trials testing new biomedical intervention. We assessed the HIV incidence and feasibility of enrolling a cohort of young women for potential participation in future clinical trials. Between March 2004 and May 2007, 594 HIV uninfected 14–30 year old women were enrolled into a longitudinal HIV risk reduction study in KwaZulu-Natal, South Africa. The overall HIV prevalence at screening in young girls below the age of 18 years was 27.6 % compared to 52.0 % in the women above 18 years, p<0.001. HIV incidence was 4.7 [95 % Confidence interval (CI) 1.5–10.9) and 6.9 (95 % CI 4.8–9.6)/100 women years (wy), p = 0.42 and pregnancy rates were 23.7 (95 % CI 14.9–35.9) and 16.4 (95 % CI 12.9–20.6)/100 wy, p = 0.29, in the women below and above 18 years respectively. Retention was similar in both groups (71.0 vs. 71.5 %, p = 0.90). This study demonstrates that the inclusion of young girls between the ages of 14 and 17 years in longitudinal studies is feasible and their inclusion in clinical trials would maintain scientific integrity and power of the study.en
dc.identifier.citationAbdool Karim, Q. et al. 2012. HIV incidence in young girls in KwaZulu-Natal, South Africa - public health imperative for their inclusion in HIV biomedical intervention trials. Aids and Behaviour. 16 (7), pp. 1870-1876.en
dc.identifier.issn1090-7165
dc.identifier.urihttp://dx.doi.org/10.1007/s10461-012-0209-yen
dc.identifier.urihttp://hdl.handle.net/10413/7953
dc.language.isoenen
dc.publisherSpringer U.S.en
dc.subjectAIDS (Disease) in women--Treatment--KwaZulu-Natal.en
dc.subjectAIDS (Disease) in adolescence--KwaZulu-Natal.en
dc.subjectHIV-postive women--Treatment--KwaZulu-Natal.en
dc.titleHIV incidence in young girls in KwaZulu-Natal, South Africa - public health imperative for their inclusion in HIV biomedical intervention trials.en
dc.typePeer reviewed journal articleen

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