The association of various HLA-A, -B and -DR loci with membranous glomerulonephritis, IgA nephropathy, and focal segmental glomerulosclerosis in KwaZulu-Natal renal patients.
| dc.contributor.advisor | Assounga, Alain Guy Honore. | |
| dc.contributor.author | Allen, Veronica. | |
| dc.date.accessioned | 2010-11-17T07:06:52Z | |
| dc.date.available | 2010-11-17T07:06:52Z | |
| dc.date.created | 2007 | |
| dc.date.issued | 2007 | |
| dc.description | Thesis (M.Med)-University of KwaZulu-Natal, 2007. | en_US |
| dc.description.abstract | This KwaZulu-Natal (KZN) based study investigates hypertension, glomerulonephritides and the rarity of IgA Nephropathy (IgAN) in Africans in association with the Human Leukocyte Antigen (HLA). A retrospective hypertensive study found a positive association with HLA-B40 (P c<0.05) and HLA-B15 (Pc<0.02) in Indians and Africans respectively. No association was found in Whites. A prospective study showed glomerulonephritides to be positively associated with HLA-A33 in Indians (Pc 0.049). No associations were found with glomerulonephritides in Africans and Whites. Combined Race groups show no HLA associations. HLA-A30; HLA-A34; HLA-A29; HLA-B42; HLA-B58; HLA-B70 and HLA-DR11 were extremely significantly higher in Africans compared to Indians and Whites (all P<0.0001). In conclusion, HLA-B40 and I 1LA-B15 are possible disease susceptibility markers in Indian and African hypertensives; HLA-A33 is a possible disease susceptibility marker for glomerulonephritides in Indians and alleles in linkage might be responsible for the rarity of IgAN in Africans but further studies need to be employed. | en_US |
| dc.identifier.uri | http://hdl.handle.net/10413/1789 | |
| dc.language.iso | en | en_US |
| dc.subject | Kidneys--Diseases--Immunological aspects. | en_US |
| dc.subject | Glomerulonephritis. | en_US |
| dc.subject | Immune complex diseases. | en_US |
| dc.subject | Kidney glomerulus--Diseases. | en_US |
| dc.subject | Theses--Nephrology. | en_US |
| dc.title | The association of various HLA-A, -B and -DR loci with membranous glomerulonephritis, IgA nephropathy, and focal segmental glomerulosclerosis in KwaZulu-Natal renal patients. | en_US |
| dc.type | Thesis | en_US |