Show simple item record

dc.creatorDezzutti, Charlene S.
dc.creatorRichardson, Barbra A.
dc.creatorMarrazzo, Jeanne M.
dc.creatorTugetman, Jessica.
dc.creatorRamjee, Gita.
dc.creatorTaha, Taha E.
dc.creatorChirenje, Zvavahera M.
dc.creatorAbdool Karim, Salim Safurdeen.
dc.creatorHillier, Sharon L.
dc.creatorHerold, Betsy C.
dc.date.accessioned2013-07-01T13:18:25Z
dc.date.available2013-07-01T13:18:25Z
dc.date.created2012
dc.date.issued2012-12-15
dc.identifier.citationDezzutti, C.S. et al. 2012. Mucosal escherichia coli bactericidal activity and immune mediators are associated with HIV-1 seroconversion in women participating in the HPTN 035 trial. J Infect Dis. 206 (12) pp. 1931-1935.en
dc.identifier.issn0022-1899
dc.identifier.urihttp://dx.doi.org/10.1093/infdis/jis555en
dc.identifier.urihttp://hdl.handle.net/10413/9241
dc.description.abstractThe mucosal environment may impact the risk for human immunodeficiency virus type 1 (HIV-1) acquisition. Immune mediators were measured in vaginal fluid collected from HPTN 035 participants who acquired HIV-1 and from those who remained HIV-1 negative (controls). Mediator concentrations were similar in samples obtained before as compared to after HIV-1 acquisition in the 8 seroconverters. Compared with controls, seroconverters were more likely to have detectable levels of HβD-2 (odds ratio [OR], 2.39; P = .005) and greater Escherichia coli bactericidal activity (OR, 1.22; P = .01) prior to seroconversion. E. coli bactericidal activity remained significant in a multivariable analysis (P = .02) and may be a biomarker for HIV-1 acquisition.en
dc.language.isoenen
dc.publisherOxford University Press on behalf of the Infectious Diseases Society of America.en
dc.subjectAIDS (Disease) in women.en
dc.subject.otherHPTN 035 trial.en
dc.subject.otherPre-exposure prophylaxis (PrEP)en
dc.titleMucosal escherichia coli bactericidal activity and immune mediators are associated with HIV-1 seroconversion in women participating in the HPTN 035 trial.en
dc.typePeer reviewed journal articleen


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record