HIV/AIDS epidemiology, pathogenesis, prevention, and treatment.
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Date
2006
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier.
Abstract
The HIV-1 pandemic is a complex mix of diverse epidemics within and between countries and regions of the world,
and is undoubtedly the defining public-health crisis of our time. Research has deepened our understanding of how
the virus replicates, manipulates, and hides in an infected person. Although our understanding of pathogenesis and
transmission dynamics has become more nuanced and prevention options have expanded, a cure or protective vaccine
remains elusive. Antiretroviral treatment has transformed AIDS from an inevitably fatal condition to a chronic,
manageable disease in some settings. This transformation has yet to be realised in those parts of the world that
continue to bear a disproportionate burden of new HIV-1 infections and are most affected by increasing morbidity
and mortality. This Seminar provides an update on epidemiology, pathogenesis, treatment, and prevention
interventions pertinent to HIV-1.
Description
Keywords
AIDS (Disease)--Pathogenesis., AIDS (Disease)--Prevention., AIDS (Disease)--Treatment., AIDS (Disease)--Epidemiology., HIV infections--Pathogenesis., HIV infections--Epidemiology., HIV infections--Transmission.
Citation
Simon, V., Ho, D.D., Abdool Karim, Q. 2006. HIV/AIDS epidemiology, pathogenesis, prevention, and treatment. The Lancet 368(9534) pp. 489-504.