Show simple item record

dc.creatorValley-Omar, Ziyaad.
dc.creatorSibeko, Sengeziwe.
dc.creatorAnderson, Jeffrey A.
dc.creatorGoodier, Sarah A.
dc.creatorWerner, Lise.
dc.creatorArney, Leslie.
dc.creatorNaranbhai, Vivek.
dc.creatorTreurnicht, Florette K.
dc.creatorAbrahams, Melissa-Rose.
dc.creatorBandawe, Gama P.
dc.creatorSwanstrom, Ronald.
dc.creatorAbdool Karim, Salim Safurdeen.
dc.creatorAbdool Karim, Quarraisha.
dc.creatorWilliamson, Carolyn.
dc.date.accessioned2012-11-23T07:39:15Z
dc.date.available2012-11-23T07:39:15Z
dc.date.created2011
dc.date.issued2011
dc.identifier.citationValley-Omar, Z. et al. 2012. CAPRISA 004 tenofovir microbicide trial: no impact of tenofovir gel on the HIV transmission bottleneck. J Infect Dis. 206 (1) pp. 35-40.en
dc.identifier.issn0022-1899
dc.identifier.urihttp://dx.doi.org/ 10.1093/infdis/jis305en
dc.identifier.urihttp://hdl.handle.net/10413/7959
dc.description.abstractAlterations of the genital mucosal barrier may influence the number of viruses transmitted from a human immunodeficiency virus–infected source host to the newly infected individual. We used heteroduplex tracking assay and single-genome sequencing to investigate the effect of a tenofovir-based microbicide gel on the transmission bottleneck in women who seroconverted during the CAPRISA 004 microbicide trial. Seventy-seven percent (17 of 22; 95% confidence interval [CI], 56%–90%) of women in the tenofovir gel arm were infected with a single virus compared with 92% (13 of 14; 95% CI, 67%–>99%) in the placebo arm (P = .37). Tenofovir gel had no discernable impact on the transmission bottleneck.en
dc.language.isoenen
dc.publisherOxford University Press.en
dc.subjectHIV infections--Treatment.en
dc.subject.otherTenofovir.en
dc.subject.otherTenofovir microbicide trials.en
dc.titleCAPRISA 004 tenofovir microbicide trial: no impact of tenofovir gel on the HIV transmission bottleneck.en
dc.typePeer reviewed journal articleen


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record