Decreased incidence of dual infections in South African subtype C-infected women compared to a cohort ten years earlier.
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Date
2011
Journal Title
Journal ISSN
Volume Title
Publisher
Mary Ann Liebert.
Abstract
Previously, we determined the incidence of dual infections in a South African cohort and its association with higher viral setpoint. Ten years later, we compare the incidence and impact of dual infections at transmission on viral setpoint in a geographically similar cohort (n=46) making use of both the heteroduplex mobility assay (HMA) and the more recent single genome amplification (SGA) approach. HIV incidence was lower in this cohort (7% compared to 18%), and we find a similar reduction in the number of dual infections (9% compared to 19%). Unlike the previous study, there was no association between either dual infection (n=4) or multivariant transmission (n=7) and disease progression. This study emphasized the importance of monitoring changes in the HIV epidemic as it may have important ramifications on our understanding of the natural history of disease.
Description
Keywords
HIV infections--Epidemiology., HIV infections--Complications., Coinfection--Epidemiology., Sexually transmitted diseases--Epidemiology., Sexually transmitted diseases--Complications.
Citation
Woodman, Z. et al. 2011. Decreased incidence of dual infections in South African subtype C-infected women compared to a cohort ten years earlier. Aids Research and Human Retroviruses. 27 (11), pp. 1167-1172.