Association of HIV-Specific and Total CD8+ T Memory Phenotypes in Subtype C HIV-1 Infection with Viral Set Point.
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Date
2009
Journal Title
Journal ISSN
Volume Title
Publisher
The American Association of Immunologists, Inc.
Abstract
Understanding early immunological events during HIV-1 infection that may set the course of disease
progression is important for identifying correlates of viral control. This study explores the association
of differentiation profiles of HIV-specific and total memory CD8+ T cells with viral set point. A
cohort of 47 HIV-1-infected individuals, with differing viral set points at 12 mo, were recruited during
acute infection. We identified that the magnitude of IFN-γ+ T cell responses at 6 mo postinfection
did not associate with viral set point at 12 mo. A subset of 16 individuals was further studied to
characterize CD8+ T cells for expression patterns of markers for memory differentiation, survival
(CD127), senescence (CD57), and negative regulation (programmed death-1). We show that viral
control and the predicted tempo of HIV disease progression in the first year of infection was
associated with a synchronous differentiation of HIV-specific and total CD8+ memory
subpopulations. At 6–9 mo postinfection, those with low viral set points had a significantly higher proportion of early differentiated HIV-specific and total memory CD8+ cells of a central memory (CD45RO+CD27+CCR7+) and intermediate memory (CD45RO−CD27+CCR7−) phenotype. Those with high viral set points possessed significantly larger frequencies of effector memory (CD45RO+CD27−CCR7−) cells. The proportions of memory subsets significantly correlated with CD38+CD8+ T cells. Thus, it is likely that a high Ag burden resulting in generalized immune
activation may drive differentiation of HIV-specific and total memory CD8+ T cells.
Description
Keywords
HIV infections--Immunology.
Citation
Burgers W.A., et al. 2009. Association of HIV-specific and total CD8+ T memory phenotypes in subtype C HIV-1 infection with viral set point. J Immunol.182(8) pp.4751–4761.