Now showing items 1-12 of 12

    • Adaptive changes in HIV-1 subtype C proteins during early infection are driven by changes in HLA-associated immune pressure. 

      Treurnicht, Florette K.; Seoighe, Cathal.; Martin, Darren P.; Wood, N.; Abrahams, Melissa-Rose.; de Assis Rosa, Debra.; Bredell, H.; Woodman, Zenda.; Hide, Winston.; Mlisana, Koleka Patience.; Abdool Karim, Salim Safurdeen.; Gray, Clive M.; Williamson, Carolyn. (Elsevier., 2009)
      It is unresolved whether recently transmitted human immunodeficiency viruses (HIV) have genetic features that specifically favour their transmissibility. To identify potential “transmission signatures”, we compared 20 ...
    • CAPRISA 004 tenofovir microbicide trial: no impact of tenofovir gel on the HIV transmission bottleneck. 

      Valley-Omar, Ziyaad.; Sibeko, Sengeziwe.; Anderson, Jeffrey A.; Goodier, Sarah A.; Werner, Lise.; Arney, Leslie.; Naranbhai, Vivek.; Treurnicht, Florette K.; Abrahams, Melissa-Rose.; Bandawe, Gama.; Swanstrom, Ronald.; Abdool Karim, Salim Safurdeen.; Abdool Karim, Quarraisha.; Williamson, Carolyn. (Oxford University Press., 2011)
      Alterations of the genital mucosal barrier may influence the number of viruses transmitted from a human immunodeficiency virus–infected source host to the newly infected individual. We used heteroduplex tracking assay and ...
    • Comparison of viral env proteins from acute and chronic infections with subtype C human immunodeficiency virus type 1 identifies differences in glycosylation and CCR5 utilization and suggests a new strategy for immunogen design. 

      Ping, Li-Hua.; Joseph, Sarah B.; Anderson, Jeffrey A.; Abrahams, Melissa-Rose.; Salazar-Gonzalez, Jesus F.; Kincer, Laura P.; Treurnicht, Florette K.; Arney, Leslie.; Ojeda, Suany.; Zhang, Ming.; Keys, Jessica.; Potter, E. Lake.; Chu, Haitao.; Moore, Penny L.; Salazar-Gonzalez, Maria.; Iyer, Shilpa.; Jabara, Cassandra.; Kirchherr, Jennifer.; Mapanje, Clement.; Ngandu, Nobubelo K.; Seoighe, Cathal.; Hoffman, Irving F.; Gao, Feng.; Tang, Yuyang.; Labranche, Celia.; Lee, Benhur.; Saville, Andrew.; Vermeulen, Marion.; Fiscus, Susan.; Morris, Lynn.; Abdool Karim, Salim Safurdeen.; Haynes, Barton F.; Shaw, George M.; Korber, Bette T.; Hahn, Beatrice H.; Cohen, Myron.; Montefiori, David C.; Williamson, Carolyn.; Swanstrom, Ronald. (American Society for Microbiology., 2013-04-24)
      Understanding human immunodeficiency virus type 1 (HIV-1) transmission is central to developing effective prevention strategies, including a vaccine.We compared phenotypic and genetic variation in HIV-1 env genes from ...
    • Decreased incidence of dual infections in South African subtype C-infected women compared to a cohort ten years earlier. 

      Woodman, Zenda.; Mlisana, Koleka Patience.; Treurnicht, Florette K.; Abrahams, Melissa-Rose.; Thebus, Ruwayida.; Abdool Karim, Salim Safurdeen.; Williamson, Carolyn. (Mary Ann Liebert., 2011-11)
      Previously, we determined the incidence of dual infections in a South African cohort and its association with higher viral setpoint. Ten years later, we compare the incidence and impact of dual infections at transmission ...
    • Evolution of an HIV glycan–dependent broadly neutralizing antibody epitope through immune escape. 

      Moore, Penny L.; Gray, Elin S.; Wibmer, Constantinos Kurt.; Bhiman, Jinal N.; Nonyane, Molati.; Hermanus, Tandile.; Sheward, Daniel.; Bajimaya, Shringkhala.; Abrahams, Melissa-Rose.; Tumba, Nancy L.; Ping, Li-Hua.; Ngandu, Nobubelo K.; Abdool Karim, Quarraisha.; Abdool Karim, Salim Safurdeen.; Swanstrom, Ronald.; Seaman, Michael S.; Williamson, Carolyn.; Morris, Lynn. (Nature Publishing Group., 2012-11)
      Neutralizing antibodies are likely to play a crucial part in a preventative HIV-1 vaccine. Although efforts to elicit broadly cross-neutralizing (BCN) antibodies by vaccination have been unsuccessful, a minority of individuals ...
    • Genital tract inflammation during early HIV-infection predicts higher plasma viral load set point in women. 

      Roberts, Lindi.; Passmore, Jo-Ann.; Mlisana, Koleka Patience.; Williamson, Carolyn.; Little, Francesca.; Bebell, Lisa M.; Walzl, Gerhard.; Abrahams, Melissa-Rose.; Woodman, Zenda.; Abdool Karim, Quarraisha.; Abdool Karim, Salim Safurdeen. (Oxford University Press., 2011)
      Background. The biggest challenge in human immunodeficiency virus type 1 (HIV-1) prevention in Africa is the high HIV-1 burden in young women. In macaques, proinflammatory cytokine production in the genital tract is necessary ...
    • Increased memory differentiation is associated with decreased polyfunctionality for HIV but not for CMV-specific CD8+ T cells. 

      Riou, Catherine.; Treurnicht, Florette K.; Abrahams, Melissa-Rose.; Mlisana, Koleka Patience.; Liu, Michael K. P.; Goonetilleke, Nilu.; Koup, Richard.; Roederer, Mario.; Abdool Karim, Salim Safurdeen.; De Bruyn, Guy.; Williamson, Carolyn.; Gray, Clive M.; Burgers, Wendy A. (American Association of Immunologists., 2012-09-15)
      The generation of polyfunctional CD8+ T cells, in response to vaccination or natural infection, has been associated with improved protective immunity. However, it is unclear whether the maintenance of polyfunctionality is ...
    • Limited Neutralizing Antibody Specificities Drive Neutralization Escape in Early HIV-1 Subtype C Infection. 

      Moore, Penny L.; Ranchobe, Nthabeleng.; Lambson, Bronwen E.; Gray, Elin S.; Cave, Eleanor.; Abrahams, Melissa-Rose.; Bandawe, Gama.; Mlisana, Koleka Patience.; Abdool Karim, Salim Safurdeen.; Williamson, Carolyn.; Morris, Lynn. (Plos, 2009-09)
      We previously showed that HIV-1 subtype C viruses elicit potent but highly type-specific neutralizing antibodies (nAb) within the first year of infection. In order to determine the specificity and evolution of these ...
    • Quantitating the multiplicity of infection with human immunodeficiency virus type 1 subtype C reveals a non-poisson distribution of transmitted variants. 

      Abrahams, Melissa-Rose.; Anderson, Jeffrey A.; Giorgi, E. E.; Seoighe, Cathal.; Mlisana, Koleka Patience.; Liu, Pinghuang.; Athreya, G. S.; Treurnicht, Florette K.; Keele, Brandon F.; Wood, N.; Salazar-Gonzalez, Jesus F.; Bhattacharya, T.; Chu, Haitao.; Hoffman, Irving F.; Galvin, S.; Mapanje, Clement.; Kazembe, P.; Thebus, Ruwayida.; Fiscus, Susan.; Hide, Winston.; Cohen, Myron.; Abdool Karim, Salim Safurdeen.; Haynes, Barton F.; Shaw, George M.; Hahn, Beatrice H.; Korber, Bette T.; Swanstrom, Ronald.; Williamson, Carolyn. (American Society for Microbiology., 2009-04)
      Identifying the specific genetic characteristics of successfully transmitted variants may prove central to the development of effective vaccine and microbicide interventions. Although human immunodeficiency virus transmission ...
    • Rapid, complex adaption of transmitted HIV-1 full-length genomes in subtype C-infected individuals with differing disease progression. 

      Abrahams, Melissa-Rose.; Treurnicht, Florette K.; Ngandu, Nobubelo K.; Goodier, Sarah A.; Marais, Jinny C.; Bredell, Helba.; Thebus, Ruwayhida.; de Assis Rosa, Debra.; Seoighe, Cathal.; Abdool Karim, Salim Safurdeen.; Gray, Clive M.; Williamson, Carolyn.; Mlisana, Koleka Patience. (Wolters Kluwer Health., 2013)
      Objective(s): There is limited information on full-length genome sequences and the early evolution of transmitted HIV-1 subtype C viruses, which constitute the majority of viruses spread in Africa. The purpose of this ...
    • Replication capacity of viruses from acute infection drives HIV-1 disease progression. 

      Selhorst, Philippe.; Combrinck, Carina.; Ndabambi, Nonkululeko.; Ismail, Sherazaan D.; Abrahams, Melissa-Rose.; Lacerda, Miguel.; Samsunder, Natasha.; Garrett, Nigel.; Abdool Karim, Quarraisha.; Abdool Karim, Salim Safurdeen.; Williamson, Carolyn. (American Society for Microbiology., 2017)
      Abstract available in pdf.
    • Vertical T cell immunodominance and epitope entropy determine HIV-1 escape. 

      Liu, Michael K. P.; Hawkins, Natalie.; Ritchie, Adam J.; Ganusov, Vitaly.; Whale, Victoria.; Brackenridge, Simon.; Li, Hui.; Pavlicek, Jeffrey W.; Cai, Fangping.; Abrahams, Melissa-Rose.; Treurnicht, Florette K.; Hraber, Peter.; Riou, Catherine.; Gray, Clive M.; Ferrari, Guido.; Tanner, Rachel.; Ping, Li-Hua.; Anderson, Jeffrey A.; Swanstrom, Ronald.; Cohen, Myron.; Abdool Karim, Salim Safurdeen.; Haynes, Barton F.; Borrow, Persephone.; Perelson, Alan S.; Shaw, George M.; Hahn, Beatrice H.; Williamson, Carolyn.; Korber, Bette T.; Gao, Feng.; Self, Steven G.; McMichael, Andrew.; Goonetilleke, Nilu. (American Society for Clinical Investigation., 2012)
      HIV-1 accumulates mutations in and around reactive epitopes to escape recognition and killing by CD8+ T cells. Measurements of HIV-1 time to escape should therefore provide information on which parameters are most important ...