School of Laboratory Medicine & Medical Sciences: Recent submissions
Now showing items 1-20 of 225
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Moringa oleifera crude aqueous leaf extract induces apoptosis in human hepatocellular carcinoma cells via the upregulation of NF-kB and IL-6/STAT3 pathway.
(2016)Abstract available in PDF file. -
Fusaric acid induces oxidative stress and apoptosis in human oesophageal cancer cells.
(2016)Abstract available in PDF file. -
Involvement of MAPK and Akt in the immunotoxicity of fusaric acid on healthy peripheral blood mononuclear cells (PBMC) and acute monocytic leukemic (Thp-1) cells.
(2015)Fusaric acid is a divalent chelator with moderate toxicity in plant and animals. However, studies lack on its effect on human models and the immune system. This study investigated the immunotoxicity of FA on PBMCs and ... -
The antiproliferative and apoptosis inducing effects of Moringa oleifera aqueous leaf extract and its synthesised gold nanoparticles - modulation of oncogenes and tumour suppressor genes in human cancer cell lines.
(2015)Cancer is one of the leading causes of global mortality. In South Africa (SA), the burden of cancer (lung and oesophageal) continues to increase. Moringa oleifera (MO), indigenous to India, is found widely in SA and used ... -
The effect of adipokines in HIV associated pre-eclampsia : (C-peptide, ghrelin, gastric inhibitory polypeptide, glucagon like peptide-1, glucagon, insulin plasminogen activator inhibitor-1 and visfatin).
(2016)Introduction: South Africa has a maternal ratio of 300 deaths/100,000 live births. Non-pregnancy related infections (mainly deaths in HIV infected pregnant women complicated by tuberculosis and pneumonia) accounts for 34.7% ... -
TylA has an essential virulence role in mycobacterium tuberculosis pathogenesis.
(2015)Mycobacterium tuberculosis (M.tb), the causative agent of the disease tuberculosis, is an ancient pathogen and a major cause of death worldwide. Although various virulence factors of M.tb have been identified, its pathogenesis ... -
An investigation into the TB/HIV manipulation of the T-cell immune response.
(2015)Abstract available in PDF file. -
Hyperglycaemic-induced regulation of SIRT3 and downstream antioxidant profile.
(2015)Hyperglycaemia increases reactive oxygen species (ROS) production and mitochondrial dysfunction which are involved in metabolic disorders. Sirtuin 3 (SIRT3) is a primary mitochondrial deacetylase that regulates mitochondrial ... -
Antibiotic resistance in mycobacterium tuberculosis : the role of genetic mutations in resistance conferring genes and efflux transporters.
(2016)Two decades after the World Health Organisation (WHO) declaration of tuberculosis (TB) as a global emergency, the disease remains a public health crisis of epic proportions. The emergence of drug resistant strains of ... -
Acquired and transmitted drug resistance in HIV-1 subtype C : implications of novel mutations on replication capacity, cleavage and drug susceptibility.
(2015)Introduction Large scale roll-out of combination antiretroviral therapy (cART) has been successful in improving the quality of life of HIV-1 infected individuals in South Africa (SA). However the development and transmission ... -
Light forge : a microfluidic high throughput platform for rapid and affordable detection of drug resistant strains of tuberculosis.
(2015)Tuberculosis is one of the most deadly infectious diseases currently plaguing the global community. Unfortunately, lack of accessible, reliable and affordable diagnostic tools in the high disease burden, and resource poor ... -
Hepatic histomorphological changes following highly active antiretroviral therapy and the intervention of hypoxis hemerocallidea in an experimental animal model.
(2015)Introduction Hepatotoxicity has remained a serious complication limiting the efficacy of highly active antiretroviral therapy (HAART) regimen. While this challenge continues to exist, finding possible solutions continues ... -
Characterizing protease inhibitor failure in HIV-1 subtype C, using ultra deep pyro-sequencing and homology modelling.
(2015)The extensive roll-out of combination antiretroviral therapy (cART) has significantly improved the life expectancy for HIV-1 infected individuals in South Africa. Despite the inclusion of potent Protease Inhibitors (PIs) ... -
Fusaric acid induces mitochondrial stress in human hepatocellular carcinoma (HepG2) cells.
(2015)Abstract available in PDF file. -
A biochemical assessment of stress response following acute and prolonged exposure to antiretroviral drugs (nucleoside reverse transcriptase inhibitors) in vitro.
(2015)Nucleoside reverse transcriptase inhibitors (NRTIs) are the most extensively used antiretroviral (ARV) drugs in highly active antiretroviral therapy (HAART). The long term use of HAART is associated with changes to metabolic ... -
Improving the efficacy of bacillus calmette guerin vaccine by concomitant inhibition of T regulatory and T helper 2 cells.
(2015)Tuberculosis (TB) remains a major threat to human population as currently Mycobacterium tuberculosis (MTB) infects nearly 33% of the global population. Annually, about one and a half million deaths are caused by tuberculosis ... -
Minority HIV-1 drug resistance mutations in patients failing highly active antiretroviral therapy (HAART).
(2014)Abstract not available. -
An investigation into the clinical, biochemical, immunological and epigenetic factors in black South Africa women with preeclampsia and HIV.
(2015)Introduction: Preeclampsia (PE) and HIV/AIDS contribute significantly to adverse maternal and perinatal outcomes globally. The treatment of PE remains empiric, however in HIV infection, highly active antiretroviral therapy ... -
Effectiveness of a monovalent human rotavirus vaccine among children of 5 years and under in KwaZulu-Natal.
(2016)Human rotavirus infection is the leading cause of gastroenteritis in infants and young children worldwide. In South Africa, gastroenteritis is a major cause of childhood morbidity and mortality in children less than 5 ... -
Fitness of multi-and extensively drug-resistant mycobacterium tuberculosis clinical strains.
(2015)The biological fitness of a pathogen is defined as its ability to reproduce, survive, cause disease and be transmitted. Drug-resistant M. tuberculosis isolates often exhibit reduced competitive ability against susceptible ...
