Now showing items 1-10 of 34
Pharmaceutical availability on newly formulated oral sustained release pellets containing the antihistamine, chlorpheniramine maleate.
The main objective of the present study was to determine the feasibility of obtaining aqueous polymer-coated pellet formulations using EudragitR NE 30 D dispersion and chlorpheniramine maleate as the model drug. Many factors ...
Hypoglycaemic and renal effects of a bioactive plant extract in streptozotocin induced diabetic rats.
Background: Evidence from our laboratories indicates that triterpene constituents of Syzygium cordatum (Hochst.) [Myrtaceae] crude leaf extracts can be used to treat diabetes mellitus. For the plant derived triterpenes to ...
HIV and the metabolic syndrome.
Abstract not available.
Grapefruit juice ameliorates nephropathy in streptozotocin induced diabetes.
Background Diabetic Nephropathy (DN) is the leading cause of end stage renal disease and mortality in diabetic patients. Over the years, medicinal plants have been used to manage diabetes and its complications. Metformin, ...
Computational insight into the glycosidase enzyme using bioinformatics tools and molecular dynamic simulations.
One of the subjects focused on by theoretical and computational studies is that of the molecular systems. Molecular dynamic simulations can provide useful insights into the dynamic, thermodynamic and structural properties ...
The toxicological properties of Scilla nervosa (Burch.) Jessop (Hyacinthaceae) in cultured HepG2 liver cells.
Background and Aims of Study. Scilla nervosa is a member of the Hyacinthaceae plant family that has been naturalised in the grasslands of Southern Africa. The bulbs are traditionally used to treat a variety of ailments. ...
Bioavailability studies on various dosage forms of the anorectic, diethylpropion hydrochloride.
The stereo-chemistry, structure activity relationships and the metabolism of the anorectic drug, diethylpropion hydrochloride, have been reviewed briefly, together with the analytical methods for the determination of this ...
The influence of the application of pharmacokinetics on the effects of theophylline utilisation upon members of the Indian population.
Theophylline is a dimethylated xanthine similar in structure to caffeine which is commonly found in tea, coffee and cola beverages (Hendeles and Weinberger, 1983; Rall, 1985). Clinically, its most important pharmacological ...
An investigation into the effects and possible mechanisms of action of cimetidine and ranitidine on the sexual behaviour of male rats.
The development of a new class of antihistamines, the H2-receptor antagonists, introduced a new era in the treatment of peptic ulcer diseases. Cimetidine, the first clinically effective H2-blocker, was introduced ...