Now showing items 1-10 of 16
Synthesis and biological activity of aloin derivatives.
This project is focused on the synthesis and biological activity of aloin and derivatives. Aloin is a C-glucoside anthrone that is found in Aloe marlothii, a common Southern African plant used in traditional medicine. ...
The use of hydroamination in the attempted synthesis of ant alkaloid 223H (xenovenine).
The ability to construct C-N bonds is of great importance to organic chemists as exemplified by the vast number of natural products, pharmaceutical agents and fine chemicals that contain such linkages. An atom efficient ...
Approaches to the total synthesis of a novel diarylheptanoid
The total synthesis of a novel diarylheptanoid isolated from a South African medicinal plant, Siphonochilus aethiopicus, was investigated. S. aethiopicus (Indungulu in Zulu) is the only South African species of the ...
Synthesis of novel pentacyclo-undecane chiral ligands for application in asymmetric catalysis
There is enormous interest in the design and development of efficient chiral ligands for asymmetric catalysis, as a result, this field has become one of the most popular areas of research in organic chemistry. This ...
Photocatalyzed tandem oxidation reactions and their application in the synthesis of quinoxalines.
No abstract available.
Structural and synthetic studies of sesquiterpenoids and flavonoids isolated from Helichrysum species
The genus Helichrysum (Asteraceae) consists of approximately 500 species worldwide, with 245 indigenous to South Africa. As a result of the large number of species, the chemistry and biological activity of several species ...
Chiral aldehydes in the synthesis of tetrahydrofurans.
Abstract available in pdf file.
Synthesis and biological evaluation of fluorinated derivatives of 2-styrylchromones and 2-thioxo imidazole dicarboxylate esters.
Two classes of fluorinated derivatives were synthesized in this work to test the effects of the fluorinated drugs in antibacterial, antioxidant and anti-platelet activity. These two classes were the 2-styrylchromones and ...
Progress towards the stereoselective synthesis of cycleanine.
The emergence of multi-drug resistance (MDR) to antimalarial and anticancer drugs has stimulated a search for novel MDR inhibitors/reversers. Bisbenzylisoquinoline alkaloids (BBIQ) are potential agents for reversing MDR, ...
Nitrogen- and phosphine-donor ruthenium(II/III) and palladium(II) complexes : synthesis and catalytic hydrogenation of ketones, alkenes and alkynes.
The ligands, 2-(2-pyridyl)benzimidazole (L1), 2-(2-pyridyl)bezothiazole (L2), and 2-(2-pyridyl)bezoxazole (L3) were prepared from o-phenylenediamine, o-aminothiophenol and 2-aminophenol, respectively, following literature ...