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dc.contributor.advisorParboosing, Raveen.
dc.creatorNaidoo, Anneta Frances.
dc.date.accessioned2011-06-02T08:14:33Z
dc.date.available2011-06-02T08:14:33Z
dc.date.created2007
dc.date.issued2007
dc.identifier.urihttp://hdl.handle.net/10413/2973
dc.descriptionThesis (M.Med.Sc.)-University of KwaZulu-Natal, 2007.en_US
dc.description.abstractKwaZulu-Natal has the highest prevalence of HIV in South Africa. The prevalence of dual infection in a normal-risk population in this region is unknown. Dual HIV infection has important implications for diagnosis, treatment response and vaccine development. This cross-sectional study aimed to establish and optimize methods for subtyping and detection of dual infection in KZN. Samples were from chronically-infected patients on ARV treatment within the ARV Rollout Programme, from sites throughout KZN. Subtyping of the samples was performed using HMA. Four samples had indeterminate results by HMA and were then cloned and sequenced. Phylogenetic analysis showed that one of the four samples was a dual infection. This study showed 1/46(2%) samples to be dually infected which suggests that the prevalence of dual infection is low in the sample population. The low prevalence of dual infection reported could be due to the low-risk profile of the sample population. It was concluded that the low prevalence of dual infection is unlikely to have a considerable impact on HIV management.en_US
dc.language.isoenen_US
dc.subjectHIV infections.en_US
dc.subjectHIV (Viruses)--Kwazulu-Natal.en_US
dc.subjectTheses--Virology.en_US
dc.subjectHIV (Viruses)en_US
dc.titleThe epidemiology of dual HIV infection in the KwaZulu-Natal Anti-Retroviral Roll-out Programme.en_US
dc.typeThesisen_US


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