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Epigenetic mechanisms, T-cell activation, and CCR5 genetics interact to regulate T-cell expression of CCR5, the major HIV-1 coreceptor.

Abstract

Abstract available in pdf.

Description

CAPRISA, 2015.

Keywords

CCR5., HIV., T cell activation., Methylation., Polymorphism.

Citation

Gornalusse, G.G., Mummidi, S., Gaitan, A.A., Jimenez, F., Ramsuran, V., Picton, A., Rogers, K., Manoharan, M.S., Avadhanam, N., Murthy, K.K., Martinez, H., Murillo, A.M., Chykarenko, Z.A., Hutt, R., Daskalakis, D., Shostakovich-Koretskaya, L., Abdool Karim, S.S., Martin, J.N., Deeks, S.G., Hecht, F., Sinclair, E., Clark, R.A., Okulicz, J., Valentine, F.T., Martinson, N., Tiemessen, C.T., Ndung’u, T., Hunt, P.W., He, W., and Ahuja, S.K. 2015. Epigenetic mechanisms, T-cell activation, and CCR5 genetics interact to regulate T-cell expression of CCR5, the major HIV-1 coreceptor. Proceedings of the National Academy of Sciences 112(34), E4762-E4771.

DOI