Antiretroviral drug regimens to prevent mother-to-child transmission of HIV : a review of scientific, program, and policy advances for sub-Saharan Africa.
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Date
2013
Journal Title
Journal ISSN
Volume Title
Publisher
Springer Science.
Abstract
Considerable advances have been made in the effort to prevent mother-to-child HIV transmission
(PMTCT) in sub-Saharan Africa. Clinical trials have demonstrated the efficacy of antiretroviral
regimens to interrupt HIV transmission through the antenatal, intrapartum, and postnatal periods.
Scientific discoveries have been rapidly translated into health policy, bolstered by substantial
investment in health infrastructure capable of delivering increasingly complex services. A new
scientific agenda is also emerging, one that is focused on the challenges of effective and
sustainable program implementation. Finally, global campaigns to “virtually eliminate” pediatric
HIV and dramatically reduce HIV-related maternal mortality have mobilized new resources and
renewed political will. Each of these developments marks a major step in regional PMTCT efforts;
their convergence signals a time of rapid progress in the field, characterized by an increased
interdependency between clinical research, program implementation, and policy. In this review,
we take stock of recent advances across each of these areas, highlighting the challenges – and
opportunities – of improving health services for HIV-infected mothers and their children across
the region.
Description
CAPRISA 2013.
Keywords
Prevention of mother-to-child HIV transmission., PMTCT., HIV., Antiretroviral prophylaxis., Sub-Saharan Africa., Global epidemic.
Citation
Chi, B.H., Stringer, J.S. and Moodley, D. 2013. Antiretroviral drug regimens to prevent mother-to-child transmission of HIV: a review of scientific, program, and policy advances for sub-Saharan Africa. Current HIV/AIDS Reports 10(2), 124-133.