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Analysis of viral inhibitory activity of cytotoxic T. Lymphocytes targeting identical epitopes restricted by different class 1 HLA alleles from the same HLA supertype. (2015)Human leukocyte antigen (HLA) polymorphism and the genetic diversity of human immunodeficiency virus (HIV) are the major obstacles for designing an effective HIV Cytotoxic T Lymphocytes (CTLs) based vaccine. Interestingly, ...
Patterns and features of HIV-1 specific CD8+ T-cell responses during acute HIV-1 infection and their association with viral control. (2015)Evidence suggests that CD8+ T-‐cells play a major role in the control of HIV-‐1 viremia and apply significant immune pressure on HIV-‐1 replication. However, the presence of virus-‐specific ...
Mapping immunodominant patterns and HLA class II restriction characteristics of HIV-specific CD4+ T cell responses in acute and chronic HIV-1 subtype C infection. (2015-08-17)Increasing evidence suggests that virus-specific CD4+ T cells contribute to immune-mediated control of HIV-1 infection. However, precise details of CD4+ T cell contribution to immune protection against HIV have not been ...